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Switching of the core transcription machinery during myogenesis.

Genes & development | September 04, 2007 |

Deato, Maria Divina E | Tjian, Robert
Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.

Abstract

Transcriptional mechanisms that govern cellular differentiation typically include sequence-specific DNA-binding proteins and chromatin-modifying activi ... nal switch had previously escaped our attention, it may represent a more general mechanism for regulating cell type-specific terminal differentiation.

Transcriptional mechanisms that govern cellular differentiation typically include sequence-specific DNA-binding proteins and chromatin-modifying activities. These regulatory factors are assumed necessary and sufficient to drive both divergent programs of proliferation and terminal differentiation. By contrast, potential contributions of the basal transcriptional apparatus to orchestrate cell-specific gene expression have been poorly explored. In order to probe alternative mechanisms that control differentiation, we have assessed the fate of the core promoter recognition complex, TFIID, during skeletal myogenesis. Here we report that differentiation of myoblast to myotubes involves the disruption of the canonical holo-TFIID and replacement by a novel TRF3/TAF3 (TBP-related factor 3/TATA-binding protein-associated factor 3) complex. This required switching of core promoter complexes provides organisms a simple yet effective means to selectively turn on one transcriptional program while silencing many others. Although this drastic but parsimonious transcriptional switch had previously escaped our attention, it may represent a more general mechanism for regulating cell type-specific terminal differentiation.

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2137fig1
Fig 1. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.
2137fig1
Fig 1. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.

Fig 1

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2137fig2
Fig 2. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.
2137fig2
Fig 2. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.

Fig 2

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2137fig3
Fig 3. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.
2137fig3
Fig 3. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.

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2137fig4
Fig 4. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.
2137fig4
Fig 4. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.

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2137fig5
Fig 5. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.
2137fig5
Fig 5. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.

Fig 5

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2137fig6
Fig 6. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.
2137fig6
Fig 6. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.

Fig 6

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Fig 7. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.
2137fig7
Fig 7. Deato, Maria Divina E, and Tjian, Robert. "Switching of the core transcription machinery during myogenesis." Genes & development 21.17 (2007): 2137-49. Web.

Fig 7

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