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Chemical technologies for probing embryonic development.

Chemical Society reviews | June 22, 2008 |

Shestopalov, Ilya A | Chen, James K
Shestopalov, Ilya A, and Chen, James K. "Chemical technologies for probing embryonic development." Chemical Society reviews 37.7 (2008): 1294-307. Web.

Abstract

Embryogenesis is a remarkable program of cell proliferation, migration, and differentiation that transforms a single fertilized egg into a complex mult ... al control of gene function and the visualization of embryonic patterning. Limitations of current approaches and future challenges are also discussed.

Embryogenesis is a remarkable program of cell proliferation, migration, and differentiation that transforms a single fertilized egg into a complex multicellular organism. Understanding this process at the molecular and systems levels will require an interdisciplinary approach, including the concepts and technologies of chemical biology. This tutorial review provides an overview of chemical tools that have been used in developmental biology research, focusing on methods that enable spatiotemporal control of gene function and the visualization of embryonic patterning. Limitations of current approaches and future challenges are also discussed.

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Fig 1. Shestopalov, Ilya A, and Chen, James K. "Chemical technologies for probing embryonic development." Chemical Society reviews 37.7 (2008): 1294-307. Web.
Nihms65923f1
Fig 1. Shestopalov, Ilya A, and Chen, James K. "Chemical technologies for probing embryonic development." Chemical Society reviews 37.7 (2008): 1294-307. Web.

Fig 1

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Fig 2. Shestopalov, Ilya A, and Chen, James K. "Chemical technologies for probing embryonic development." Chemical Society reviews 37.7 (2008): 1294-307. Web.
Nihms65923f2
Fig 2. Shestopalov, Ilya A, and Chen, James K. "Chemical technologies for probing embryonic development." Chemical Society reviews 37.7 (2008): 1294-307. Web.

Fig 2

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Fig 3. Shestopalov, Ilya A, and Chen, James K. "Chemical technologies for probing embryonic development." Chemical Society reviews 37.7 (2008): 1294-307. Web.
Nihms65923f3
Fig 3. Shestopalov, Ilya A, and Chen, James K. "Chemical technologies for probing embryonic development." Chemical Society reviews 37.7 (2008): 1294-307. Web.

Fig 3

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Fig 4. Shestopalov, Ilya A, and Chen, James K. "Chemical technologies for probing embryonic development." Chemical Society reviews 37.7 (2008): 1294-307. Web.
Nihms65923f4
Fig 4. Shestopalov, Ilya A, and Chen, James K. "Chemical technologies for probing embryonic development." Chemical Society reviews 37.7 (2008): 1294-307. Web.

Fig 4

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Fig 5. Shestopalov, Ilya A, and Chen, James K. "Chemical technologies for probing embryonic development." Chemical Society reviews 37.7 (2008): 1294-307. Web.
Nihms65923f5
Fig 5. Shestopalov, Ilya A, and Chen, James K. "Chemical technologies for probing embryonic development." Chemical Society reviews 37.7 (2008): 1294-307. Web.

Fig 5

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