Pdf

Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium.

Proceedings of the National Academy of Sciences of the United States of America | December 09, 2008 |

Fu, Yong | Wey, Shiuan | Wang, Miao | Ye, Risheng | Liao, Chun-Peng | Roy-Burman, Pradip | Lee, Amy S
Fu, Wey, et al. "Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium." Proceedings of the National Academy of Sciences of the United States of America 105.49 (2008): 19444-9. Web.

Abstract

GRP78/BiP has recently emerged as a novel biomarker for aggressive prostate cancer. Here, we report that homozygous deletion of Grp78 specifically in m ... proach to stop prostate cancer and potentially other cancers resulting from the loss of PTEN tumor suppression and/or activation of the oncogenic AKT.

GRP78/BiP has recently emerged as a novel biomarker for aggressive prostate cancer. Here, we report that homozygous deletion of Grp78 specifically in mouse prostate epithelium suppresses prostate tumorigenesis without affecting postnatal prostate development and growth. Mouse prostates with double conditional knockout of Grp78 and Pten exhibit normal histology and cytology, in contrast to the invasive adenocarcinoma in mouse prostates with Pten inactivation. AKT activation in Pten null prostate epithelium is inhibited by Grp78 homozygous deletion, corresponding with suppression of AKT phosphorylation by GRP78 knockdown in prostate cancer cell line. Thus, inactivation of GRP78 may represent a previously undescribed approach to stop prostate cancer and potentially other cancers resulting from the loss of PTEN tumor suppression and/or activation of the oncogenic AKT.

High Discussion
Low Discussion
Paper
Fig 1
Fig 2
Fig 3

Summary of The Overall Paper

Click to enter summary

Sign up to leave a summary.


Sign up to leave a summary.



Comments
Zpq9990858570001
Fig 1. Fu, Wey, et al. "Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium." Proceedings of the National Academy of Sciences of the United States of America 105.49 (2008): 19444-9. Web.
Zpq9990858570001
Fig 1. Fu, Wey, et al. "Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium." Proceedings of the National Academy of Sciences of the United States of America 105.49 (2008): 19444-9. Web.

Fig 1

Click to enter summary

Sign up to leave a summary.


Click to list methods

Sign up to leave a summary.



Comments
Zpq9990858570002
Fig 2. Fu, Wey, et al. "Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium." Proceedings of the National Academy of Sciences of the United States of America 105.49 (2008): 19444-9. Web.
Zpq9990858570002
Fig 2. Fu, Wey, et al. "Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium." Proceedings of the National Academy of Sciences of the United States of America 105.49 (2008): 19444-9. Web.

Fig 2

Click to enter summary

Sign up to leave a summary.


Click to list methods

Sign up to leave a summary.



Comments
Zpq9990858570003
Fig 3. Fu, Wey, et al. "Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium." Proceedings of the National Academy of Sciences of the United States of America 105.49 (2008): 19444-9. Web.
Zpq9990858570003
Fig 3. Fu, Wey, et al. "Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium." Proceedings of the National Academy of Sciences of the United States of America 105.49 (2008): 19444-9. Web.

Fig 3

Click to enter summary

Sign up to leave a summary.


Click to list methods

Sign up to leave a summary.



Comments