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Controlling hair follicle signaling pathways through polyubiquitination.

The Journal of investigative dermatology | April 13, 2008 |

Huntzicker, Erik G | Oro, Anthony E
Huntzicker, Erik G, and Oro, Anthony E. "Controlling hair follicle signaling pathways through polyubiquitination." The Journal of investigative dermatology 128.5 (2008): 1081-7. Web.

Abstract

Hair follicle development and maintenance require precise reciprocal signaling interactions between the epithelium and underlying dermis. Three major d ... ew how polyubiquitination regulates the stability and interaction of key signaling components that control hair follicle development and regeneration.

Hair follicle development and maintenance require precise reciprocal signaling interactions between the epithelium and underlying dermis. Three major developmental signaling pathways, Wnt, Sonic hedgehog, and NF-kappaB/Edar, are indispensable for this process and, when aberrantly activated, can lead to skin and appendage neoplasms. Recent data point to protein polyubiquitination as playing a central role in regulating the timing, duration, and location of signaling. Here we review how polyubiquitination regulates the stability and interaction of key signaling components that control hair follicle development and regeneration.

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Nihms-118330-f0001
Fig 1. Huntzicker, Erik G, and Oro, Anthony E. "Controlling hair follicle signaling pathways through polyubiquitination." The Journal of investigative dermatology 128.5 (2008): 1081-7. Web.
Nihms-118330-f0001
Fig 1. Huntzicker, Erik G, and Oro, Anthony E. "Controlling hair follicle signaling pathways through polyubiquitination." The Journal of investigative dermatology 128.5 (2008): 1081-7. Web.

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Nihms-118330-f0002
Fig 2. Huntzicker, Erik G, and Oro, Anthony E. "Controlling hair follicle signaling pathways through polyubiquitination." The Journal of investigative dermatology 128.5 (2008): 1081-7. Web.
Nihms-118330-f0002
Fig 2. Huntzicker, Erik G, and Oro, Anthony E. "Controlling hair follicle signaling pathways through polyubiquitination." The Journal of investigative dermatology 128.5 (2008): 1081-7. Web.

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