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Wnt signaling and injury repair.

Cold Spring Harbor perspectives in biology | August 01, 2012 |

Whyte, Jemima L | Smith, Andrew A | Helms, Jill A
Whyte, Jemima L, Smith, Andrew A, and Helms, Jill A. "Wnt signaling and injury repair." Cold Spring Harbor perspectives in biology 4.8 (2012): a008078. Web.

Abstract

Wnt signaling is activated by wounding and participates in every subsequent stage of the healing process from the control of inflammation and programme ... in the injury repair process. These data provide a foundation for potential Wnt-based therapeutic strategies aimed at stimulating tissue regeneration.

Wnt signaling is activated by wounding and participates in every subsequent stage of the healing process from the control of inflammation and programmed cell death, to the mobilization of stem cell reservoirs within the wound site. In this review we summarize recent data elucidating the roles that the Wnt pathway plays in the injury repair process. These data provide a foundation for potential Wnt-based therapeutic strategies aimed at stimulating tissue regeneration.